Study reveals connection between gum disease and structural damage in brain white matter

Poor systemic health in one organ system can adversely affect others. A recent study reports an association between periodontal disease and an elevated risk of structural abnormalities in cerebral white matter, which is responsible for transmitting signals throughout the central nervous system. Although the findings are not yet definitive, they indicate that chronic oral inflammation may contribute to deleterious effects on the brain. This suggests that maintaining good oral hygiene could support not only periodontal health but also the integrity of white matter. The investigation, conducted by researchers at the University of South Carolina, focused on white matter hyperintensities (WMHs) radiological markers of cerebral small vessel disease (CSVD). CSVD involves pathological changes in the body. This study demonstrates an association between periodontal disease and increased white matter hyperintensity burden, suggesting that oral health may contribute to aspects of brain health that are not yet fully understood. The research team analyzed dental examinations and neuroimaging data from 1,143 adult participants. Individuals with periodontal disease (n = 800) exhibited a higher mean white matter hyperintensity (WMH) volume 2.83% of total brain volume compared with 2.52% in participants without periodontal disease. After adjusting for covariates known to influence both periodontal status and cerebrovascular health, the analysis indicated that participants with gum disease had a 56% higher likelihood of belonging to the subgroup with the greatest white matter damage.

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