Maternal Immunization is a preventive strategy that protects pregnant individuals and their infants by leveraging transplacental antibody transfer and early-life immune priming. Vaccination during pregnancy reduces the risk of severe disease for mothers while conferring passive immunity to newborns during the most vulnerable early months of life. This session explores the immunological basis, safety considerations, and programmatic approaches that support effective maternal immunization across diverse health systems.

Pregnancy introduces unique immunological adaptations that balance tolerance of the fetus with protection against infection. These physiological changes influence vaccine response, antibody kinetics, and the efficiency of placental transfer. Such dynamics are frequently discussed at leading Vaccine Conferences, where experts examine how timing, antigen selection, and maternal immune status affect both maternal protection and neonatal outcomes. This session highlights how immunology guides evidence-based recommendations for vaccination during pregnancy.

A central focus of this session is vaccination during pregnancy, encompassing vaccines recommended to prevent influenza, pertussis, and other infections with high neonatal impact. Research continues to refine optimal dosing windows that maximize antibody levels at birth without compromising maternal safety. This session examines how immune memory, gestational age, and prior exposure shape response, and how clinical data inform guidance for routine and outbreak settings.

Maternal immunization programs also require careful consideration of communication, access, and trust. Vaccine confidence during pregnancy is influenced by provider counseling, safety surveillance, and culturally appropriate messaging. The session addresses how integrated antenatal care, real-world safety monitoring, and clear risk–benefit communication improve uptake. Equity is emphasized, recognizing that barriers to prenatal care can limit access to protective vaccines for both mothers and infants.

Beyond routine care, maternal immunization contributes to broader public health goals by reducing infant morbidity, lowering healthcare utilization, and strengthening outbreak preparedness. Coordinated surveillance and post-licensure studies ensure ongoing evaluation of effectiveness and safety. By connecting immunological principles with clinical practice and policy, this session provides a comprehensive view of how maternal immunization advances maternal and neonatal health outcomes.